Pubmed (externer Link, öffnet neues Fenster)
Google Scholar (externer Link, öffnet neues Fenster)
2025
Sanson A, Demarchi L, Köck A, Ebner K, Bosch OJ (2025) Pup defence in lactating rats: The underlying neuropeptide signalling and their interactions in the nucleus accumbens shell. bioRxiv 10.29.620799. https://www.biorxiv.org/content/10.1101/2024.10.29.620799v1 (externer Link, öffnet neues Fenster)
Sanson A, Demarchi L, Rocaboy E, Bosch OJ (2025) Increased CRF-R1 transmission in the nucleus accumbens shell facilitates maternal neglect in lactating rats and mediates anxiety-like behaviour in a sex-specific manner. Neuropharmacology 265: 110256. https://doi.org/10.1016/j.neuropharm.2024.110256 (externer Link, öffnet neues Fenster)
Fischer L, Paschke B, Gareis F, Schumacher M,Liere P, Hiergeist A, Gessner A, Rupprecht R, Neumann ID, Bosch OJ (2025) The translocator protein 18 kDa (TSPO) ligand etifoxine in an animal model of anxiety: Line- and sex-dependent effects on emotionality, stress reactivity, spine density, oxytocin receptors, steroids, and microbiome composition. Neuropharmacology 266: 110282. https://doi.org/10.1016/j.neuropharm.2024.110282 (externer Link, öffnet neues Fenster)
2024
Demarchi L, Sanson A, Boos AL, Bosch OJ (2024) Long-term offspring loss in lactating rats: Neurobiological and emotional consequences in a novel animal model. bioRxiv 2025.02.17.634946. https://www.biorxiv.org/content/10.1101/2025.02.17.634946v1 (externer Link, öffnet neues Fenster)
Bosch OJ (2024) To bond or not to bond: Neuroendocrinology might have the answer. Neuroendocrine Briefings 62. https://www.neuroendo.org.uk/doc/BSN%20Neuroendocrine%20Briefing%2062.pdf (externer Link, öffnet neues Fenster)
Demarchi L, Sanson A, Bosch OJ (2024) Neurobiological traces of grief: Examining the impact of offspring loss after birth on rat mothers’ brain and stress-coping behavior in the first week postpartum. Neurosci Appl 104065. https://doi.org/10.1016/j.nsa.2024.104065 (externer Link, öffnet neues Fenster)
Sanson A, Krieg P, Schramm MM, Kellner K, Maloumby R, Klampfl SM, Brunton PJ, Bosch OJ (2024) CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats. Neurobiol Stress 100631. https://doi.org/10.1016/j.ynstr.2024.100631 (externer Link, öffnet neues Fenster)
Sanson A, Demarchi L, Bosch OJ (2024) Neuroendocrine basis of impaired mothering in rodents. In: Caldwell HK, Albers HE (eds) Neuroendocrinology of Behavior and Emotions. Masterclass in Neuroendocrinology, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-031-51112-7_4 (externer Link, öffnet neues Fenster)
2023
Winter J, Meyer M, Berger I, Royer M, Bianchi M, Kuffner K, Peters S, Stang S, Langgartner D, Hartmann F, Schmidtner AK, Reber SO, Bosch OJ, Bludau A, Slattery DS, van den Burg EH, Jurek B, Neumann ID (2023) Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety. Mol Psychiatry 28:4742-4755. https://doi.org/10.1038/s41380-021-01141-x (externer Link, öffnet neues Fenster)
Gryksa K, Schmidtner AK, Masis-Calvo M, Rodriguez-Villagra OA, Havasi A,Wirobski G, Maloumby R, Jägle H, Bosch OJ, Slattery DA, Neumann ID (2023) Selective breeding of rats for high (HAB) and low (LAB) anxiety-related behaviour: A unique model for comorbid depression and social dysfunctions . Neurosci Biobehav Rev 152: 105292. https://doi.org/10.1016/j.neubiorev.2023.105292 (externer Link, öffnet neues Fenster)
Demarchi L, Sanson A, Bosch OJ (2023) Brief vs long maternal separation in lactating rats: consequences on maternal behavior, emotionality, and brain oxytocin receptor binding. J Neuronedocrinol e13252. https://doi.org/10.1111/jne.13252 (externer Link, öffnet neues Fenster)
Pawluski JL, Brunton PJ, Bosch OJ (2023) The 7th International Meeting on the Neuroscience of Parenting. J Neuroendocrinol e13321. https://doi.org/10.1111/jne.13321 (externer Link, öffnet neues Fenster)
2022
Sanson A, Bosch OJ (2022) Dysfunctions of brain oxytocin signaling: Implications for poor mothering. Neuropharmacology 211: 109049. https://doi.org/10.1016/j.neuropharm.2022.109049 (externer Link, öffnet neues Fenster)
2021
Demarchi L, Pawluski JL, Bosch OJ (2021) The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn. Peptides 143: 170593. https://doi.org/10.1016/j.peptides.2021.170593 (externer Link, öffnet neues Fenster)
Pohl TT, Jung O, Di Benedetto B, Young LJ, Bosch OJ (2021) Microglia react to partner loss in a sex- and brain site-specific manner in prairie voles. Brain Behav Immun 96: 168-186. https://doi.org/10.1016/j.bbi.2021.05.026 (externer Link, öffnet neues Fenster)
Oliveira VEdM, Lukas M, Wolf HN, Durante E, Lorenz A, Mayer AL, Bludau A, Bosch OJ, Grinevich V, Egger V, de Jong TR, Neumann ID (2021) Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. Nat Commun 12: 2900. https://doi.org/10.1038/s41467-021-23064-5 (externer Link, öffnet neues Fenster)
2020
Gryksa K, Mittmann L, Bauer A, Peterlik D, Flor PJ, Uschold-Schmidt N, Bosch OJ (2020) Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice. Genes Brain Behav 19:e12627. https://doi.org/10.1111/gbb.12627 (externer Link, öffnet neues Fenster)
2019
Robinson KJ, Bosch OJ, Levkowitz G, Busch KE, Jarman A, Ludwig M (2019) Social creatures: model animal systems for studying the neuroendocrine mechanisms of social behaviour. J Neuroendocrinol e12807. https://doi.org/10.1111/jne.12807 (externer Link, öffnet neues Fenster)
Pawluski JL, Champagne FA, Bosch OJ (2019) Parental Brain Conference 2018. J Neuroendocrinol e12789. https://doi.org/10.1111/jne.12789 (externer Link, öffnet neues Fenster)
Stolzenberg DS, Hernandez-D'Anna KL, Bosch OJ, Lonstein JS (2019) Maternal behavior from a neuroendocrine perspective. In: Oxford Research Encyclopedia of Neuroscience. Oxford University Press. https://doi.org/10.1093/acrefore/9780190264086.013.237 (externer Link, öffnet neues Fenster)
Klampfl SM, Bosch OJ (2019) Mom doesn't care: when increased brain CRF system activity leads to maternal neglect in rodents. Front Neuroendocrinol 53: 100735. https://doi.org/10.1016/j.yfrne.2019.01.001 (externer Link, öffnet neues Fenster)
Bayerl DS, Klampfl SM, Bosch OJ (2019) More than reproduction - central GnRH antagonism decreases maternal aggression in lactating rats. J Neuroendocrinol e12709. https://doi.org/10.1111/jne.12709 (externer Link, öffnet neues Fenster)
Bayerl DS, Bosch OJ (2019) Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats. Genes Brain Behav 18: e12517. https://doi.org/10.1111/gbb.12517 (externer Link, öffnet neues Fenster)
Pohl TT, Young LJ, Bosch OJ (2019) Lost connections: Oxytocin and the neural, physiological and behavioural consequences of disrupted relationships. Int J Psychophysiol 136: 54-63. https://doi.org/10.1016/j.ijpsycho.2017.12.011 (externer Link, öffnet neues Fenster)
2018
Bosch OJ, Young LJ (2018) Oxytocin and social relationships: From attachment to bond disruption. Curr Top Behav Neurosci 35: 97-117. https://doi.org/10.1007/7854_2017_10 (externer Link, öffnet neues Fenster)
Klampfl SM, Bosch OJ (2018) When mothers neglect their offspring: an activated CRF system in the BNST is detrimental for maternal behavior. Arch Womens Ment Health 22: 409-415. https://doi.org/10.1007/s00737-018-0897-z (externer Link, öffnet neues Fenster)
Klampfl SM, Schramm MM, Gaßner BM, Hübner K, Seasholtz AF, Brunton PJ, Bayerl DS, Bosch OJ (2018) Maternal stress and the MPOA: Activation of CRF receptor 1 impairs maternal behavior and triggers local oxytocin release in lactating rats. Neuropharmacology 133: 440-450. https://doi.org/10.1016/j.neuropharm.2018.02.019 (externer Link, öffnet neues Fenster)
Bosch OJ, Pohl TT, Neumann IN, Young LJ (2018) Abandoned prairie vole mothers show normal maternal care but altered emotionality: Potential influence of the brain corticotropin-releasing factor system. Behav Brain Res 341: 114-121. https://doi.org/10.1016/j.bbr.2017.12.034 (externer Link, öffnet neues Fenster)
Menon R, Grund T, Zoicas I, Althammer F, Fiedler D, Biermeier V, Bosch OJ, Hiraoka Y, Nishimori K, Eliava M, Grinevich V, Neumann ID (2018) Oxytocin signalling in the lateral septum prevents social fear during lactation. Curr Biol 28: 1066-1078.e6. https://doi.org/10.1016/j.cub.2018.02.044 (externer Link, öffnet neues Fenster)
2017
Bosch OJ (2017) Look behind the eyes - vasopressin rules the day. J Physiol 595: 3245. https://doi.org/10.1113/jp274223 (externer Link, öffnet neues Fenster)
2016
Klampfl SM, Schramm MM, Stinnett GS, Bayerl DS, Seasholtz AF, Bosch OJ (2016) CRF-binding protein modulates aspects of maternal behavior under stressful conditions and supports a hypo-anxious state in lactating rats. Horm Behav 84: 136-144. https://doi.org/10.1016/j.yhbeh.2016.06.009 (externer Link, öffnet neues Fenster)
Brown CH, Bosch OJ (2016) Vasopressin and oxytocin: Conductors of the symphony of physiology and behaviour. J Neuroendocrinology 28: e12386. https://doi.org/10.1111/jne.12386 (externer Link, öffnet neues Fenster)
Bayerl DS, Hönig JN, Bosch OJ (2016) Vasopressin V1a, but not V1b, receptors within the PVN of lactating rats mediate maternal care and anxiety-related behaviour. Behav Brain Res 305: 18-22. https://doi.org/10.1016/j.bbr.2016.02.020 (externer Link, öffnet neues Fenster)
Bosch OJ, Dabrowska J, Modi ME, Johnson ZV, Keebaugh AC, Barrett CE, Ahern TH, Guo JD, Grinevich V, Rainnie DG, Neumann ID, Young LJ (2016) Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles. Psychoneuroendocrinology 64: 66-78. https://doi.org/10.1016/j.psyneuen.2015.11.011 (externer Link, öffnet neues Fenster)
Klampfl SM, Brunton PJ, Bayerl DS, Bosch OJ (2016) CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism. Psychoneuroendocrinology 64: 89-98. https://doi.org/10.1016/j.psyneuen.2015.11.015 (externer Link, öffnet neues Fenster)
Bayerl DS, Kaczmarek V, Jurek B, van den Burg EH, Neumann ID, Gaßner BM, Klampfl SM, Bosch OJ (2016) Antagonism of V1b receptors promotes maternal motivation to retrieve pups in the MPOA and impairs pup-directed behavior during maternal defense in the mpBNST of lactating rats. Horm Behav 79: 18-27. https://doi.org/10.1016/j.yhbeh.2015.12.003 (externer Link, öffnet neues Fenster)
2015
de Jong TR, Menon R, Bludau A, Grund T, Biermeier V, Klampfl SM, Jurek B, Bosch OJ, Hellhammer J, Neumann ID (2015) Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the Trier Social Stress Test (TSST): an oxytocin challenge study. Psychoneuroendocrinology 62: 381-388. https://doi.org/10.1016/j.psyneuen.2015.08.027 (externer Link, öffnet neues Fenster)
2014
Bayerl DS, Klampfl SM, Bosch OJ (2014) Central V1b receptor antagonism in lactating rats: Impairment of maternal care but not of maternal aggression. J Neuroendocrinol 26: 918-926. https://doi.org/10.1111/jne.12226 (externer Link, öffnet neues Fenster)
Bosch OJ, Slattery DA, Neumann ID (2014) The 5th Parental Brain Conference. J Neuroendocrinol 26: 625-626. https://doi.org/10.1111/jne.12189 (externer Link, öffnet neues Fenster)
Klampfl SM, Brunton PJ, Bayerl DS, Bosch OJ (2014) Hypoactivation of CRF receptors, predominantly type 2, in the medial-posterior BNST is vital for adequate maternal behavior in lactating rats. J Neurosci 34: 9665-9676. https://doi.org/10.1523/jneurosci.4220-13.2014 (externer Link, öffnet neues Fenster)
2013
Bosch OJ (2013) Maternal aggression in rodents: Brain oxytocin and vasopressin mediate pup defence. Phil Trans R Soc B: 368 20130085. https://doi.org/10.1098/rstb.2013.0085 (externer Link, öffnet neues Fenster)
Klampfl SM, Neumann ID, Bosch OJ (2013) Reduced brain CRF receptor activation is required for adequate maternal care and maternal aggression in lactating rats. Eur J Neurosci 38: 2742-2750. https://doi.org/10.1111/ejn.12274 (externer Link, öffnet neues Fenster)
2012
Okimoto N, Bosch OJ, Slattery DA, Pflaum K, Matsushita H, Wei F-Y, Ohmori M, Nishiki T-I, Ohmori I, Hiramatsu Y, Matsui H, Neumann ID, Tomizawa K (2012) RGS2 mediates the anxiolytic effect of oxytocin. Brain Res 1453: 26-33. https://doi.org/10.1016/j.brainres.2012.03.012 (externer Link, öffnet neues Fenster)
Bosch OJ, Neumann ID (2012) Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action. Horm Behav 61: 293-303. https://doi.org/10.1016/j.yhbeh.2011.11.002 (externer Link, öffnet neues Fenster)
2011
Caughey S, Klampfl SM, Bishop VR, Pförtsch J, Neumann ID, Bosch OJ, Meddle SL (2011) Changes in the intensity of maternal aggression and central oxytocin and vasopressin V1a receptors across the peripartum period in the rat. J Neuroendocrinol 23: 1113-1124. https://doi.org/10.1111/j.1365-2826.2011.02224.x (externer Link, öffnet neues Fenster)
Bosch OJ (2011) Maternal nurturing is dependent on her innate anxiety: The behavioral roles of brain oxytocin and vasopressin. Horm Behav 59: 201-212. https://doi.org/10.1016/j.yhbeh.2010.11.012 (externer Link, öffnet neues Fenster)
Kessler MS*, Bosch OJ*, Bunck M, Landgraf R, Neumann ID (2011) Maternal care differs in mice bred for high versus low trait anxiety: Impact of brain vasopressin and cross-fostering. Soc Neurosci 6: 156-168. *shared 1st authorship https://doi.org/10.1080/17470919.2010.495567 (externer Link, öffnet neues Fenster)
2010
Bosch OJ, Pförtsch J, Beiderbeck DI, Landgraf R, Neumann ID (2010) Maternal behaviour is associated with vasopressin release in the medial preoptic area and bed nucleus of the stria terminalis in the rat. J Neuroendocrinol 22: 420-429. https://doi.org/10.1111/j.1365-2826.2010.01984.x (externer Link, öffnet neues Fenster)
Bosch OJ, Neumann ID (2010) Vasopressin released within the central amygdala promotes maternal aggression. Eur J Neurosci 31: 883-891. https://doi.org/10.1111/j.1460-9568.2010.07115.x (externer Link, öffnet neues Fenster)
Waldherr M, Nyuyki K, Maloumby R, Bosch OJ, Neumann ID (2010) Attenuation of the neuronal stress responsiveness and corticotrophin releasing hormone synthesis after sexual activity in male rats. Horm Behav 57: 222-229. https://doi.org/10.1016/j.yhbeh.2009.11.006 (externer Link, öffnet neues Fenster)
2009
Bosch OJ, Nair HP, Ahern TH, Neumann ID, Young LJ (2009) The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent. Neuropsychopharmacology 34: 1406-1415. https://doi.org/10.1038/npp.2008.154 (externer Link, öffnet neues Fenster)
Lucassen PJ, Bosch OJ, Jousma E, Kromer S, Andrews R, Seckl J, Neumann ID (2009) Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low anxiety: possible key role of placental 11ß-hydroxysteroid dehydrogenase type 2. Eur J Neurosci 29: 97-103. https://doi.org/10.1111/j.1460-9568.2008.06543.x (externer Link, öffnet neues Fenster)
2008
Bosch OJ, Neumann ID (2008) Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. PNAS 105: 17139-17144. https://doi.org/10.1073/pnas.0807412105 (externer Link, öffnet neues Fenster)
Neumann ID, Bosch OJ (2008) Maternal stress adaptations peripartum: Mom's innate anxiety determines maternal care and aggression. In: Neurobiology of the parental brain. pp. 115-130. Bridges R [ed.]; Elsevier. https://psycnet.apa.org/doi/10.1016/B978-0-12-374285-8.00008-1 (externer Link, öffnet neues Fenster)
Blume A, Bosch OJ, Miklos S, Torner L, Wales L, Waldherr M, Neumann ID (2008) Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus. Eur J Neurosci 27: 1947-1956. https://doi.org/10.1111/j.1460-9568.2008.06184.x (externer Link, öffnet neues Fenster)
2007
Bosch OJ, Sartori SB, Singewald N, Neumann ID (2007) Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams during maternal aggression: Regulation by oxytocin. Stress 10: 261-270. https://doi.org/10.1080/10253890701223197 (externer Link, öffnet neues Fenster)
Bosch OJ, Müsch W, Bredewold R, Slattery DA, Neumann ID (2007) Prenatal stress increases HPA-axis activity and impairs maternal care in lactating female offspring: implications for postpartum mood disorder. Psychoneuroendocrinology 32: 267-278. https://doi.org/10.1016/j.psyneuen.2006.12.012 (externer Link, öffnet neues Fenster)
Douglas AJ, Meddle SL, Kroemer S, Muesch W, Bosch OJ, Neumann ID (2007) Social stress induces hypothalamo-pituitary-adrenal axis responses in lactating rats bred for high trait anxiety. Eur J Neurosci 25: 1599-1603. https://doi.org/10.1111/j.1460-9568.2007.05380.x (externer Link, öffnet neues Fenster)
2006
Bosch OJ, Krömer SA, Neumann ID (2006) Prenatal stress: opposite effects on anxiety and hypothalamic expression of vasopressin and corticotropin-releasing hormone in rats selectively bred for high and low anxiety. Eur J Neurosci 23: 541-551. https://doi.org/10.1111/j.1460-9568.2005.04576.x (externer Link, öffnet neues Fenster)
Bosch OJ, Waldherr SA, Nair HP, Young LJ, Neumann ID (2006) Viral vector-mediated overexpression of oxytocin receptors in the amygdala of virgin rats increases aggression and reduces anxiety. Front Neuroendocrinol 27: 124-125. https://www.sciencedirect.com/science/article/pii/S0091302206003128/pdfft?md5=ae1190fec05b6aae7183508da4165e33&pid=1-s2.0-S0091302206003128-main.pdf (externer Link, öffnet neues Fenster)
2005
Bosch OJ, Meddle SL, Beiderbeck DI, Douglas AJ, Neumann ID (2005) Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci 25: 6807-6815. https://doi.org/10.1523/jneurosci.1342-05.2005 (externer Link, öffnet neues Fenster)
Neumann ID, Krömer S, Bosch OJ (2005) Effects of psycho-social stress during pregnancy on neuroendocrine and behavioural parameters in lactation depend on the genetically determined stress vulnerability. Psychoneuroendocrinology 30: 791-806. https://doi.org/10.1016/j.psyneuen.2005.03.008 (externer Link, öffnet neues Fenster)
Neumann ID, Wigger A, Krömer S, Frank E, Landgraf R, Bosch OJ (2005) Differential effects of periodic maternal separation on adult stress coping in a rat model of extremes in trait anxiety. Neuroscience 132: 867-877. https://doi.org/10.1016/j.neuroscience.2005.01.034 (externer Link, öffnet neues Fenster)
Douglas AJ, Meddle SL, Toschi N, Bosch OJ, Neumann ID (2005) Reduced activity of the noradrenergic system in the paraventricular nucleus at the end of pregnancy: implications for stress hyporesponsiveness. J Neuroendocrinol 17: 40-48. https://doi.org/10.1111/j.1365-2826.2005.01272.x (externer Link, öffnet neues Fenster)
Ebner K, Bosch OJ, Kromer SA, Singewald N, Neumann ID (2005) Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids. Neuropsychopharmacology 30: 223-230. https://doi.org/10.1016/j.neuroscience.2003.11.028 (externer Link, öffnet neues Fenster)
2004
Bosch OJ, Krömer SA, Brunton PJ, Neumann ID (2004) Release of oxytocin in the hypothalamic paraventricular nucleus, but not amygdala or septum in lactating residents and virgin intruders during maternal defence. Neuroscience 124: 439-448. https://doi.org/10.1016/j.neuroscience.2003.11.028 (externer Link, öffnet neues Fenster)
2003
Douglas AJ, Brunton PJ, Bosch OJ, Russel JA, Neumann ID (2003) Neuroendocrine responses to stress in mice: hyporesponsiveness in pregnancy and parturition. Endocrinology 144: 5268-5276. https://doi.org/10.1210/en.2003-0461 (externer Link, öffnet neues Fenster)
Neumann ID, Bosch OJ, Toschi N, Torner L, Douglas AJ (2003) No stress response of the hypothalamo-pituitary-adrenal axis in parturient rats: lack of involvement of brain oxytocin. Endocrinology 144: 2473-2479. https://doi.org/10.1210/en.2003-0037 (externer Link, öffnet neues Fenster)
2000
Bosch OJ, Geier M, Boeckh J (2000) Contribution of fatty acids to olfactory host finding of female Aedes aegypti. Chem Senses 25: 323-330. https://doi.org/10.1093/oxfordjournals.chemse.a014042 (externer Link, öffnet neues Fenster)
1999
Geier M, Bosch OJ, Boeckh J (1999) Influence of odour plume structure on upwind flight of mosquitoes towards hosts. J Exp Biol 202: 1639-1648. https://doi.org/10.1242/jeb.202.12.1639 (externer Link, öffnet neues Fenster)
Geier M, Bosch OJ, Boeckh J (1999) Ammonia as an attractive component of host odour for the yellow fever mosquito, Aedes aegypti. Chem Senses 24: 647-653. https://doi.org/10.1093/chemse/24.6.647 (externer Link, öffnet neues Fenster)